The optimization algorithms are ready. The systems around them need to catch up.

April 21, 2026

The optimization algorithms are ready. The systems around them need to catch up.

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Last week I had the privilege of speaking at Flow Chemistry Europe 2026 in Málaga - a big thank you to the @Flow Chemistry Society for organizing such an excellent conference.

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Within chemistry, I believe the flow & automation community remains one of the most open, forward-thinking groups when it comes to embracing new technologies. That makes conversations like the one I want to share here possible.

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Algorithms like Bayesian optimization have been around for decades. And they work. But for chemistry, I believe, the bottleneck has never really been the algorithm. It's the system around it - the reliability of the hardware, the traceability of the data, the robustness of the analytics pipeline.

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A loop you can't reproduce is a loop you can't learn from.

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In my talk I argued that true autonomy in flow chemistry isn't something you jump to. It's something you earn, bottom-up, across three horizons:

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  1. Trust first. Capture not just what you set, but the realised conditions along with versioned analytics. 

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  1. Acceleration. When campaigns stop being isolated and start informing each other, your historical data stops being a record of the past and becomes a competitive advantage.

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  1. Autonomy. Multi-agent workflows where each agent masters one part of the system - optimization, reactor control, analytical QC - and together they close the loop for you.

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This is exactly what we are tackling at @ReactWise.

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Reliable learning enables reuse - and reuse compounds into autonomy.

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