The optimization algorithms are ready. The systems around them need to catch up.

April 21, 2026

The optimization algorithms are ready. The systems around them need to catch up.

Last week I had the privilege of speaking at Flow Chemistry Europe 2026 in Málaga - a big thank you to the @Flow Chemistry Society for organizing such an excellent conference.

Within chemistry, I believe the flow & automation community remains one of the most open, forward-thinking groups when it comes to embracing new technologies. That makes conversations like the one I want to share here possible.

Algorithms like Bayesian optimization have been around for decades. And they work. But for chemistry, I believe, the bottleneck has never really been the algorithm. It's the system around it - the reliability of the hardware, the traceability of the data, the robustness of the analytics pipeline.

A loop you can't reproduce is a loop you can't learn from.

In my talk I argued that true autonomy in flow chemistry isn't something you jump to. It's something you earn, bottom-up, across three horizons:

  1. Trust first. Capture not just what you set, but the realised conditions along with versioned analytics. 

  1. Acceleration. When campaigns stop being isolated and start informing each other, your historical data stops being a record of the past and becomes a competitive advantage.

  1. Autonomy. Multi-agent workflows where each agent masters one part of the system - optimization, reactor control, analytical QC - and together they close the loop for you.

This is exactly what we are tackling at @ReactWise.

Reliable learning enables reuse - and reuse compounds into autonomy.

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