A 50% decrease in the number of experiments while achieving 90% in reaction yield - Here is how we supported OnDemand Pharmaceuticals

A 50% decrease in the number of experiments while achieving 90% in reaction yield - Here is how we supported Luke Rogers from OnDemand Pharmaceuticals accelerate their process development and gain deeper insights:

When On Demand set out to optimize a complex continuous flow esterification for a small molecule API, they partnered with @ReactWise to streamline their process development. The result?

Over 50% reduction in experimental workload while achieving 90% reaction yield - without compromising on insight or confidence.

The key objectives: increase reaction yield, reduce two unwanted impurities, and optimize color-related molecular properties by varying 6 different process parameters - all within a highly constrained experimental budget.

Typically, this type of work would rely heavily on expert intuition and trial-and-error. Instead, our platform enabled a data-driven path from the start, delivering recommendations grounded in predictive modeling and molecular information.

Using our Bayesian optimization platform and our proprietary chemical descriptor database, we modeled their system in real time and delivered high-quality experimental recommendations - even with minimal input data.

Why it worked:

→ The process had clearly defined inputs and outputs

→ Our chemical modeling engine learned the system quickly using descriptors

→ Tight collaboration ensured that models aligned with real-world chemistry

Getting started was simple:

• Onboarding took less than 30 minutes
• We provided regular check-in calls to ensure optimal usage
• Our team remained available on-demand to support every step

This collaboration is a powerful example of what’s possible when machine learning meets chemical process development - fast, reliable, and insight-rich optimization, even in data-scarce environments.

On Demand Pharma is one of America’s most advanced drug production solution - and we’re proud to support their mission.

If you're working on API development and want to reduce timelines, material use, and uncertainty please drop me a pm.

Photo credit: On Demand Phamaceuticals Inc.

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